![]() Rather, PV and pernicious anemia may coexist, as Livestrong suggests. ![]() However, it does not mean that the B12 supplementation caused the PV to occur. This would tend to lead to higher vitamin B12 blood levels, even in people being treated for pernicious anemia. Moreover, Pernicious Anemia Relief offers the possibility that the PV disease process may cause the liver to release stored vitamin B12 into the bloodstream. Nevertheless, an elevated red blood cell count does not necessarily lead to a diagnosis of PV, according to Mayo Clinic, which identifies other conditions a high count might point to. PV is characterized by the overproduction of red blood cells. Since vitamin B12 supports red blood cell production (via ODS), it is conceivable that when a vitamin B12 deficiency is treated with high dosage supplementation, the result may be the overproduction of red blood cells. In support of the former, Livestrong explains that the PV disease process begins in the bone marrow, leading to the overproduction of red blood cells. For all populations at risk for vitamin B12 deficiency, B12 supplementation can be critical to optimal health and well-being. So too are those dealing with ongoing food insecurity. Some foods have been fortified with B-12, including some breakfast cereals and some nutritional yeast products. Vitamin B-12 is mainly found in meat, eggs and milk, so people who don't eat these types of foods may need to take B-12 supplements. Further, the elderly population is, as a statistical matter, at higher risk of malnutrition, as compared with younger adults. Low levels of vitamin B-12 can be caused by: Diet. The reason is that the body becomes less efficient at absorbing B12 after age 60. Others at risk include those over the age of 60, according to a 2021 study published in Nutrients. Untreated, vitamin B-12 deficiency can lead to neurological problems, such as persistent tingling in the hands and feet or problems with balance. The same may be true of folic acid, which is commonly taken in supplement form during pregnancy, per a 2022 study published in Advances in Nutrition. In addition, large doses of vitamin C may deplete vitamin B12 stores in the body, per HSIS. ![]() ![]() These medications include proton pump inhibitors (which are sometimes prescribed for people with GERD), the gout medication colchicine, the diabetes drug metformin, and H2 blockers such as Pepcid. In addition, those who take certain medications may be at increased risk for B12 deficiency, per Healthline. ![]()
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